![]() To address this lacuna in current scientific evidence, we compared ABM/P-15 with other commonly used bone graft substitute materials in lumbar interbody fusion surgeries namely rhBMP-2, and DBM in terms of their clinical and radiological outcomes as well as the side effect profile. ![]() However, in the cases of lumbar fusion surgeries, more evidence is needed to establish its efficiency and safety. The use of ABM/P-15 has been well established in single level anterior cervical fusion surgeries. This P-15 imitates the cell-binding domain of type one collagen and triggers biomechanical signals which ultimately result in new bone formation. ![]() The ABM/P-15 (anorganic bone matrix/15-amino acid peptide fragment) is a synthetically manufactured P-15 collagen peptide fragment, that is adsorbed on ABM and suspended in an inert hydroge. Pre-operative Oswestry disability index scores were 52.7☑8.02, 55.4☑6.8, and 53.56☑9.6 ( p=0.751) in ABM/P-15, rhBMP-2, and DBM groups, which post-operatively reduced to 33.77☑5.52, 39.42☑6.47, and 38.3☑5.89 ( p=0.412) and further to 15.74☘.3, 17.41☑0.45, and 16.76☙.81 ( p=0.603), respectively at the last follow-up.Īllografts, demineralized bone matrix (DBM), ceramics and recombinant bone morphogenic protein-2 (rhBMP-2) are some of the substitutes that have been investigated to replace autografts for achieving interbody fusion, with varying success rates. Patient characteristics like age, gender, bone mineral density, smoking history, and presence of diabetes mellitus were comparable amongst the three groups. ABM/P-15, rhBMP-2, and DBM were used in 46, 44, and 50 patients, respectively.
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